All Pets are Off: A Collection of Hairy Columns

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Hairy Carry: A visit to the vet doesn’t have to be a bad trip

My mom heard me scream, ran into the bathroom and found me huddled in the corner of the shower in the fetal position, crying and naked as the day I was born. Good thing my mom came to my rescue. Even that would scare Spiderman. April E.

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Clark read on pbs. So much for NyQuil. She can be reached at , ext. Start a dialogue, stay on topic and be civil. If you don't follow the rules , your comment may be deleted. Manieri column: Democrats risk credibility with impeachment gambit September 27, I would not like to give anyone the impression that I am some kind of enthusiast. They also bite children, bark ceaselessly and wreck stuff.

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But I will happily watch a dachshund puppy run through tall grass for an hour. Facebook Twitter Pinterest. Television Dogs Pets Channel 4 reviews. Reuse this content. Order by newest oldest recommendations. Show 25 25 50 All. Threads collapsed expanded unthreaded. Loading comments… Trouble loading? In the first conditioning session mice were injected i. On Day 3, during the second conditioning session, all mice were injected with saline and confined for 1 hour in the opposite i.

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  • Associated Data?

P compartment. The second conditioning session was performed the following day since CNO effects last for 9 hours On Day 4 and Day 5 the first and second conditioning sessions were repeated, respectively. The time between the ip injections of CNO or saline and the placement of the mice in the compartment was between min, which is compatible with the time that is needed for CNO to start having an effect On Day 6, the mice were tested for their side compartment preference by placing them in the center compartment and allowing them to freely explore the entire apparatus for 30 min post test.


Following the pre-test, on the first day of the conditioning session the mice were injected with saline and confined in the I. The second day of conditioning the mice were injected with CNO except for the saline control mice and placed in the I. On the 3 rd and 4 th day of conditioning the 1 st and 2 nd sessions of conditioning were repeated, respectively.

On the 6 th day the mice were tested for their preference in the three compartment arena. Statistical analysis of all other metrics was performed using a repeated two way mixed model ANOVA unless otherwise stated with each group as the between-subject variable and pre-training vs. Author contributions : S. National Center for Biotechnology Information , U. Author manuscript; available in PMC Jul Sophia Vrontou , 1 Allan M. Wong , 1, 2 Kristofer K.

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Richard Koerber , 4 and David J. Anderson 1, 2. Allan M. Kristofer K. Richard Koerber. David J. Author information Copyright and License information Disclaimer. Correspondence and requests for materials should be directed to D. Copyright notice. The publisher's final edited version of this article is available at Nature. See other articles in PMC that cite the published article. Associated Data Supplementary Materials 1. Abstract Stroking of the skin produces pleasant sensations that can occur during social interactions with conspecifics, such as grooming 1.

Open in a separate window. Figure 1. In vivo calcium imaging in genetically defined subsets of primary sensory neurons a , Schematic illustrating AAV infection. Figure 2. Activation of MrgprD fibers by pinching a, b , Schematics illustrating pinching a and stroking b stimuli. Figure 3. Figure 4. Neonatal mouse viral injections P1-P2 pups were removed from their cage and briefly submerged in an ice water bath inside a latex glove with their head up, until they appear anesthetized min. Electrophysiological Recording in Ex Vivo Skin-Nerve preparations The ex - vivo somatosensory system preparation has been described in detail previously Calcium Imaging Mice two months or older were sedated by I.

Stimulus delivery during imaging experiments Mechanical stimuli Brushing stimuli were delivered using a sable paint brush No. Behaviour The conditioned place preference CPP protocol was based on previous studies 13 , Supplementary Material 1 Click here to view. Footnotes Author contributions : S. The skin as a social organ.

Exp Brain Res. The neurophysiology of unmyelinated tactile afferents. Neurosci Biobehav Rev. Dunbar RI. The social role of touch in humans and primates: behavioural function and neurobiological mechanisms. Discriminative touch and emotional touch.

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A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Liu Q, et al. Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch. Nat Neurosci.